Reduction in mouse allergen exposure is associated with greater lung function growth.

ABSTRACT:

Background

Current childhood asthma therapies have little effect on lung function trajectory.

Objective

We sought to determine whether mouse allergen exposure reduction is associated with lung function growth in mouse-sensitized/exposed asthmatic children.

Methods

Three hundred fifty mouse-sensitized/exposed asthmatic children (5-17 years old) were enrolled in a 1-year randomized trial of integrated pest management plus education versus education alone. Prebronchodilator/postbronchodilator spirometry was performed at baseline and 6 and 12 months, and bedroom floor mouse allergen levels were measured every 3 months. Mouse allergen reduction was defined as a 75% or greater decrease in mouse allergen levels from baseline. Treatment groups were combined for analyses becau

SUBMITTER: Grant T 

PROVIDER: S-EPMC7046077 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature