Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens.

ABSTRACT: The development of chemotherapies against eukaryotic pathogens is especially challenging because of both the evolutionary conservation of drug targets between host and parasite, and the evolution of strain-dependent drug resistance. There is a strong need for new nontoxic drugs with broad-spectrum activity against trypanosome parasites such as Leishmania and Trypanosoma. A relatively untested approach is to target macromolecular interactions in parasites rather than small molecular interactions, under the hypothesis that the features specifying macromolecular interactions diverge more rapidly through coevolution. We computed tRNA Class-Informative Features in humans and independently in eight distinct clades of trypanosomes, identifying parasite-specific informative features, including bas

SUBMITTER: Kelly P 

PROVIDER: S-EPMC7046186 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature