A profile of circulating vascular progenitor cells in human neovascular age-related macular degeneration.

ABSTRACT: BACKGROUND/OBJECTIVE:A subset of neovascular age-related macular degeneration (nvAMD) subjects appears to be refractory to the effects of anti-VEGF treatment and require frequent intravitreal injections. The vascular phenotype of the choroidal neovascular (CNV) lesions may contribute to the resistance. Animal studies of CNV lesions have shown that cells originating from bone marrow are capable of forming varying cell types in the lesions. This raised the possibility of a similar cell population in human nvAMD subjects. MATERIALS AND METHODS:Blood draws were obtained from subjects with active nvAMD while patients were receiving standard of care anti-VEGF injections. Subjects were classified as refractory or non-refractory to anti-VEGF treatment based on previous number of injections in the

SUBMITTER: Catchpole T 

PROVIDER: S-EPMC7046286 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature