Intrahost cytomegalovirus population genetics following antibody pretreatment in a monkey model of congenital transmission.

ABSTRACT: Human cytomegalovirus (HCMV) infection is the leading non-genetic cause of congenital birth defects worldwide. While several studies have addressed the genetic composition of viral populations in newborns diagnosed with HCMV, little is known regarding mother-to-child viral transmission dynamics and how therapeutic interventions may impact within-host viral populations. Here, we investigate how preexisting CMV-specific antibodies shape the maternal viral population and intrauterine virus transmission. Specifically, we characterize the genetic composition of CMV populations in a monkey model of congenital CMV infection to examine the effects of passively-infused hyperimmune globulin (HIG) on viral population genetics in both maternal and fetal compartments. In this study, 11 seronegative, pr

SUBMITTER: Vera Cruz D 

PROVIDER: S-EPMC7046290 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature