Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC7046511 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20200115 2
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting F ...[more]