Effect of the antipsychotic drug haloperidol on arrhythmias during acute myocardial infarction in a porcine model.

ABSTRACT: Patients receiving psychiatric medication, like the antipsychotic drug haloperidol, are at an increased risk of sudden cardiac death (SCD). Haloperidol blocks the cardiac rapidly-activating delayed rectifier potassium current, thereby increasing electrical dispersion of repolarization which can potentially lead to arrhythmias. Whether these patients are also at a higher risk to develop SCD during an acute myocardial infarction (AMI) is unknown. AMI locally shortens action potential duration, which might further increase repolarization dispersion and increase the risk of arrhythmia in the presence of haloperidol compared to without. Our aim was to test whether treatment with haloperidol implies an increased risk of SCD when eventually experiencing AMI. Twenty-eight female Danish Landrace pi

SUBMITTER: Sattler SM 

PROVIDER: S-EPMC7046512 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature