Sensitivity of the Kaiser Permanente early-onset sepsis calculator: A systematic review and meta-analysis.

ABSTRACT:

Background

Determining which babies should receive antibiotics for potential early onset sepsis (EOS) is challenging. We performed a meta-analysis quantifying how many EOS cases might be 'missed' using the Kaiser Permanente electronic calculator, compared with National Institute for Health and Care Excellence (NICE) guidelines.

Methods

A systematic literature search was carried out for studies citing the article in which the calculator was publicised. Studies were eligible if they presented data evaluating the calculator, either by retrospective case review or prospective cohort study. The primary outcome measure was numbers of culture positive EOS cases where the calculator did not recommend empirical antibiotics, but NICE guidelines would have. Data were pooled using a ran

SUBMITTER: Pettinger KJ 

PROVIDER: S-EPMC7046522 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature