Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men.

ABSTRACT: Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential mechanism linking mLOY to disease risk in 206,353 UK males. Associations between mLOY, detected by genotyping arrays, and blood cell counts were assessed by multivariable linear models adjusted for relevant risk factors. Among the participants, mLOY was detected in 39,809 men. We observed associations between mLOY and reduced erythrocyte count (-0.009 [-0.014, -0.005] × 10¹² cells/L, p = 2.75 × 10^-5) and elevated thrombocyte count (5.523 [4.862, 6.183] × 10⁹ cells/L, p = 2.32 × 10^-60) and leukocyte count (0.218 [0.198, 0.239] × 10⁹ cells/L, p = 9.22 × 10

SUBMITTER: Lin SH 

PROVIDER: S-EPMC7046668 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature