VEGF-A165b levels are reduced in breast cancer patients at primary diagnosis but increase after completion of cancer treatment.

ABSTRACT: The antiangiogenic splice variant VEGF-A165b is downregulated in a variety of cancer entities, but little is known so far about circulating plasma levels. The present analysis addresses this question and examines circulating VEGF-A/VEGF-A165b levels in a collective of female high-risk breast cancer patients over the course of treatment. Within the SUCCES-A trial 205 patients were recruited after having received primary breast surgery. Using ELISA VEGF-A/VEGF-A165b concentrations were determined and correlated to clinical characteristics (1) before adjuvant chemotherapy, (2) four weeks and (3) two years after therapy and compared to healthy controls (n = 107). VEGF_165b levels were significantly elevated after completion of chemotherapy. Within the breast cancer cohort, VEGF-A165b

SUBMITTER: Karsten MM 

PROVIDER: S-EPMC7046696 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature