Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection.

ABSTRACT: Respiratory syncytial virus (RSV) infection in mouse and human lung is associated with oxidative injury and pathogenic inflammation. RSV impairs antioxidant responses by increasing the degradation of transcription factor NRF2, which controls the expression of several antioxidant enzyme (AOE) genes, including catalase. Since catalase is a key enzyme for the dismutation of virus-mediated generation of hydrogen peroxide (H₂O₂) we developed a model of intranasal supplementation of polyethylene glycol-conjugated catalase (PG-CAT) for RSV-infected mice. The results of our study show that PG-CAT supplementation was able to increase specific enzymatic activity along with reduction in H₂O₂ in the airways and had a significant protective effect against RSV

SUBMITTER: Ansar M 

PROVIDER: S-EPMC7046725 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature