LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer.

ABSTRACT:

Background

The prognosis of colorectal cancer (CRC) is still challenging to evaluate or predict. Recently, long non-coding RNAs (lncRNAs) have been found to play an important role in tumorigenesis and prognosis, however, few lncRNAs have been identified in CRC progression. We aimed to establish a lncRNA signature to improve prognosis prediction of CRC.

Methods

In the present study, we profiled lncRNA expression with a lncRNA-mining approach in two CRC data sets from Gene Expression Ominus (GEO) (GSE39582, N = 557 and GSE17538, N = 200). LncRNAs were analyzed to determine a prognostic signature by Cox regression and Robust likelihood-based survival model. We identified seven lncRNAs that significantly associated with the disease free survival (DFS) in the traini

SUBMITTER: Huang R 

PROVIDER: S-EPMC7047379 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature