Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.

ABSTRACT: Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations.Methods: We conducted genome-wide analyses across three independent studies and meta-analyzed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studi

SUBMITTER: Allen RJ 

PROVIDER: S-EPMC7047454 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature