Magnetic resonance imaging of mean cell size in human breast tumors.

ABSTRACT:

Purpose

Cell size is a fundamental characteristic of all tissues, and changes in cell size in cancer reflect tumor status and response to treatments, such as apoptosis and cell-cycle arrest. Unfortunately, cell size can currently be obtained only by pathological evaluation of tumor tissue samples obtained invasively. Previous imaging approaches are limited to preclinical MRI scanners or require relatively long acquisition times that are impractical for clinical imaging. There is a need to develop cell-size imaging for clinical applications.

Methods

We propose a clinically feasible IMPULSED (imaging microstructural parameters using limited spectrally edited diffusion) approach that can characterize mean cell sizes in solid tumors. We report the use of a combination of pulse s

SUBMITTER: Xu J 

PROVIDER: S-EPMC7047520 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature