Quantitative 3D myocardial perfusion with an efficient arterial input function.

ABSTRACT:

Purpose

The purpose of this study was to further develop and combine several innovative sequence designs to achieve quantitative 3D myocardial perfusion. These developments include an optimized 3D stack-of-stars readout (150 ms per beat), efficient acquisition of a 2D arterial input function, tailored saturation pulse design, and potential whole heart coverage during quantitative stress perfusion.

Theory and methods

All studies were performed free-breathing on a Prisma 3T MRI scanner. Phantom validation was used to verify sequence accuracy. A total of 21 subjects (3 patients with known disease) were scanned, 12 with a rest only protocol and 9 with both stress (regadenoson) and rest protocols. First pass quantitative perfusion was performed with gadoteridol (0.075 mmol/kg).

SUBMITTER: Mendes JK 

PROVIDER: S-EPMC7047561 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature