TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.

ABSTRACT: The activation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle coordinates systemic metabolic responses to exercise¹. Autophagy-a lysosomal degradation pathway that maintains cellular homeostasis²-is upregulated during exercise, and a core autophagy protein, beclin 1, is required for AMPK activation in skeletal muscle³. Here we describe a role for the innate immune-sensing molecule Toll-like receptor 9 (TLR9)⁴, and its interaction with beclin 1, in exercise-induced activation of AMPK in skeletal muscle. Mice that lack TLR9 are deficient in both exercise-induced activation of AMPK and plasma membrane localization of the GLUT4 glucose transporter in skeletal muscle, but are not deficient in autophagy. TLR9 binds beclin

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7047589 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature