IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.

ABSTRACT: Coeliac disease is a complex, polygenic inflammatory enteropathy caused by exposure to dietary gluten that occurs in a subset of genetically susceptible individuals who express either the HLA-DQ8 or HLA-DQ2 haplotypes^1,2. The need to develop non-dietary treatments is now widely recognized³, but no pathophysiologically relevant gluten- and HLA-dependent preclinical model exists. Furthermore, although studies in humans have led to major advances in our understanding of the pathogenesis of coeliac disease⁴, the respective roles of disease-predisposing HLA molecules, and of adaptive and innate immunity in the development of tissue damage, have not been directly demonstrated. Here we describe a mouse model that reproduces the overexpression of interleukin-15 (IL

SUBMITTER: Abadie V 

PROVIDER: S-EPMC7047598 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature