Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.

ABSTRACT: Intestinal Na⁺-nutrient cotransport depends on claudin-2 and claudin-15 mediated Na⁺ recycling. Expression of these proteins is coordinately regulated during postnatal development. While expression of claudin-2 and claudin-15 has been studied in inflammatory bowel disease (IBD) and celiac disease (CD), it has not been assessed in other malabsorptive diseases, and no reports have compared expression in children and adults. We used quantitative immunofluorescence microscopy to assess claudin-2 and claudin-15 expression in duodenal biopsies from children and adults with malabsorptive disease and healthy controls. Consistent with previous work in rodents, claudin-2 expression in healthy children was markedly greater, and claudin-15 expression was less, than that in adults

SUBMITTER: Ong MLDM 

PROVIDER: S-EPMC7047618 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature