Amide Proton Transfer Imaging in Predicting Isocitrate Dehydrogenase 1 Mutation Status of Grade II/III Gliomas Based on Support Vector Machine.

ABSTRACT:

Background

To compare the efficacies of univariate and radiomics analyses of amide proton transfer weighted (APT_W) imaging in predicting isocitrate dehydrogenase 1 (IDH1) mutation of grade II/III gliomas.

Methods

Fifty-nine grade II/III glioma patients with known IDH1 mutation status were prospectively included (IDH1 wild type, 16; IDH1 mutation, 43). A total of 1044 quantitative radiomics features were extracted from APT_W images. The efficacies of univariate and radiomics analyses in predicting IDH1 mutation were compared. Feature values were compared between two groups with independent t-test and receiver operating characteristic (ROC) analysis was applied to evaluate the predicting efficacy of each feature. C

SUBMITTER: Han Y 

PROVIDER: S-EPMC7047712 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature