Virological Outcome Measures During Analytical Treatment Interruptions in Chronic HIV-1-Infected Patients.

ABSTRACT:

Background

Analytical treatment interruptions (ATIs) are essential in research on HIV cure. However, the heterogeneity of virological outcome measures used in different trials hinders the interpretation of the efficacy of different strategies.

Methods

We conducted a retrospective analysis of viral load (VL) evolution in 334 ATI episodes in chronic HIV-1-infected patients collected from 11 prospective studies. Quantitative (baseline VL, set point, delta set point, VL, and delta VL at given weeks after ATI, peak VL, delta peak VL, and area under the rebound curve) and temporal parameters (time to rebound [TtR], set point, peak, and certain absolute and relative VL thresholds) were described. Pairwise correlations between parameters were analyzed, and potential confounding fact

SUBMITTER: Feher C 

PROVIDER: S-EPMC7047957 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature