Use of thiazide diuretics for the prevention of recurrent kidney calculi: a systematic review and meta-analysis.

ABSTRACT:

Background

Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unclear. We aimed to evaluate the effect and safety of thiazide diuretics on recurrent kidney calculi.

Methods

The PubMed, Cochrane Library, and EMBASE databases were systematically searched using the keywords thiazide diuretics and kidney calculi to identify randomized controlled trials (RCTs). The primary outcome was the incidence of recurrent kidney calculi, and the secondary outcome was the 24-h urinary calcium level. The pooled risk ratio (RR), risk difference (RD), standardized mean difference (SMD), and 95% confidence interval (CI) were calculated. The ev

SUBMITTER: Li DF 

PROVIDER: S-EPMC7048029 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature