Chronic whipworm infection exacerbates Schistosoma mansoni egg-induced hepatopathology in non-human primates.

ABSTRACT: BACKGROUND:Schistosomiasis continues to inflict significant morbidity and mortality in the tropical and subtropical regions of the world. The disease endemicity overlaps with the transmission of other parasitic diseases. Despite the ubiquity of polyparasitism in tropical regions, particularly in rural communities, little is known about the impact of multiple helminth infections on disease progression. In this pilot study, we describe the influence of chronic Trichuris trichiura infection on Schistosoma mansoni egg-induced hepatopathology in infected baboons. METHODS:Baboons with or without underlying whipworm infection were challenged with S. mansoni cercariae to establish schistosomiasis. Adult S. mansoni worms were recovered by perfusion and enumerated, hepatic granulomas were quantified

SUBMITTER: Le L 

PROVIDER: S-EPMC7048111 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature