Development of Oral Care Chip, a novel device for quantitative detection of the oral microbiota associated with periodontal disease.

ABSTRACT: Periodontal disease, the most prevalent infectious disease in the world, is caused by biofilms formed in periodontal pockets. No specific bacterial species that can cause periodontitis alone has been found in any study to date. Several periodontopathic bacteria are associated with the progress of periodontal disease. Consequently, it is hypothesized that dysbiosis of subgingival microbiota may be a cause of periodontal disease. This study aimed to investigate the relationship between the subgingival microbiota and the clinical status of periodontal pockets in a quantitative and clinically applicable way with the newly developed Oral Care Chip. The Oral Care Chip is a DNA microarray tool with improved quantitative performance, that can be used in combination with competitive PCR to quantita

SUBMITTER: Nozawa A 

PROVIDER: S-EPMC7048280 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature