Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies.

ABSTRACT: Neurotropic viral infections continue to pose a serious threat to human and animal wellbeing. Host responses combatting the invading virus in these infections often cause irreversible damage to the nervous system, resulting in poor prognosis. Rabies is the most lethal neurotropic virus, which specifically infects neurons and spreads through the host nervous system by retrograde axonal transport. The key pathogenic mechanisms associated with rabies infection and axonal transmission in neurons remains unclear. Here we studied the pathogenesis of different field isolates of lyssavirus including rabies using ex-vivo model systems generated with mouse primary neurons derived from the peripheral and central nervous systems. In this study, we show that neurons activate selective and compartmental

SUBMITTER: Sundaramoorthy V 

PROVIDER: S-EPMC7048299 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature