Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice.

ABSTRACT:

Introduction

Two common responses to stress include elevated circulating glucocorticoids and impaired luteinizing hormone (LH) secretion. We have previously shown that a chronic stress level of corticosterone can impair ovarian cyclicity in intact mice by preventing follicular-phase endocrine events.

Objective

This study is aimed at investigating if corticosterone can disrupt LH pulses and whether estradiol is necessary for this inhibition.

Methods

Our approach was to measure LH pulses prior to and following the administration of chronic corticosterone or cholesterol in ovariectomized (OVX) mice treated with or without estradiol, as well as assess changes in arcuate kisspeptin (Kiss1) neuronal activation, as determined by co-expression with c-Fos.

Results

In OV

SUBMITTER: Kreisman MJ 

PROVIDER: S-EPMC7048652 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature