Response to nicotine following overnight smoking abstinence during short-term progesterone treatment in women.

ABSTRACT: Preclinical and clinical literature suggest that sex hormones impact tobacco use behaviors in women. The goal of this double-blind crossover laboratory study was to examine the effect of oral exogenous progesterone (200 mg twice per day) versus placebo on nicotine response using measures of motor speed and cognitive function in women following overnight smoking abstinence. We hypothesized that increased progesterone would blunt the nicotine response whereby producing less change in motor speed and cognition in response to nicotine exposure. Female smokers, age 18-35, were randomized to participate in two 9-day crossover testing weeks. Participants completed a lab session following overnight abstinence where they were administered nicotine nasal spray and asked to complete measures of immed

SUBMITTER: Allen S 

PROVIDER: S-EPMC7048655 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature