Anti-Mullerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone.

ABSTRACT:

Study question

Does treatment of constitutional delay of growth and puberty (CDGP) in boys with aromatase inhibitor letrozole (Lz) or conventional low-dose testosterone (T) have differing effects on developing seminiferous epithelium?

Summary answer

Anti-Müllerian hormone (AMH) declined similarly in both treatment groups, and the two Sertoli cell-derived markers (AMH and inhibin B (iB)) exhibited differing responses to changes in gonadotrophin milieu.

What is known already

Boys with CDGP may benefit from puberty-inducing medication. Peroral Lz activates gonadotrophin secretion, whereas intramuscular low-dose T may transiently suppress gonadotrophins and iB.

Study design, size, duration

Sera of 28 boys with CDGP who participated in a randomised, controlled, open

SUBMITTER: Kohva E 

PROVIDER: S-EPMC7048712 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature