MCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation.

ABSTRACT: Commitment to cell cycle entry and cellular duplication is a tightly coordinated and regulated process. Once initiated, a series of multiple checkpoints ensure both accurate genomic replication and chromosomal separation. In the event of unsuccessful cell division, parallel pathways exist that induce the cell to undergo programmed cell death, or apoptosis. At the center of such stress-induced, intrinsic apoptotic regulation lies the BCL2 family of pro- and anti-apoptotic regulatory proteins. In a proliferative state the balance of pro- and anti-apoptotic signaling proteins would be expected to favor an excess population of anti-apoptotic members. While the anti-apoptotic BCL2 family member, MCL1, has been identified to oversee mitotic progression, direct communication between the BCL2 fami

SUBMITTER: Whitaker RH 

PROVIDER: S-EPMC7048787 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature