Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention.

ABSTRACT: With recent advances in our understanding of the continuous pathophysiological changes that begin many years prior to symptom onset, it is now apparent that Alzheimer's disease cannot be adequately described by discrete clinical stages, but should also incorporate the continuum of biological changes that precede and underlie the clinical representation of the disease. By jointly considering longitudinal changes of all available biomarkers and clinical assessments, variation within individuals can be integrated into a single continuous measure of disease progression and used to identify the earliest pathophysiological changes. Disease time, a measure of disease severity, was estimated using a Bayesian latent time joint mixed-effects model applied to an array of imaging, biomarker and neurop

SUBMITTER: Insel PS 

PROVIDER: S-EPMC7048875 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature