Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions.

ABSTRACT:

Introduction

The pathophysiological increase in microvascular permeability plays a well-known role in the onset and progression of diseases like sepsis and atherosclerosis. However, how interactions between neutrophils and the endothelium alter vessel permeability is often debated.

Methods

In this study, we introduce a microfluidic, silicon-membrane enabled vascular mimetic (μSiM-MVM) for investigating the role of neutrophils in inflammation-associated microvascular permeability. In utilizing optically transparent silicon nanomembrane technology, we build on previous microvascular models by enabling in situ observations of neutrophil-endothelium interactions. To evaluate the effects of neutrophil transmigration on microvascular model permeability, we established and v

SUBMITTER: Khire TS 

PROVIDER: S-EPMC7048879 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature