Genetic Predisposition and Salt Sensitivity in a Chinese Han Population: The EpiSS Study.

ABSTRACT:

Objectives

Genome-wide association studies and candidate gene studies have found many single nucleotide polymorphisms (SNPs) that affect salt sensitivity (SS). We constructed a polygenic risk score (PRS) to estimate the joint effect of these SNPs on SS.

Methods

We recruited 762 Chinese participants into the study. An unweighted PRS was constructed using 42 known genetic risk variants associated with SS or salt sensitivity blood pressure. A modified Sullivan's acute oral saline load and diuresis shrinkage test was used to detect salt sensitivity. Logistic regression was used to estimate the joint effect of the SNPs on SS both overall and after stratification by hypertension.

Results

The mean age of the participants was 57.1 years, and most of them were female (77.4%).

SUBMITTER: Liu K 

PROVIDER: S-EPMC7048915 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature