Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer.

ABSTRACT: Cinobufotalin injection, extracted from the skin of Chinese giant salamander or black sable, has good clinical effect against lung cancer. However, owing to its complex composition, the pharmacological mechanism of cinobufotalin injection has not been fully clarified. This study aimed to explore the mechanism of action of cinobufotalin injection against lung cancer using network pharmacology and bioinformatics. Compounds of cinobufotalin injection were determined by literature retrieval, and potential therapeutic targets of cinobufotalin injection were screened from Swiss Target Prediction and STITCH databases. Lung-cancer-related genes were summarized from GeneCards, OMIM, and DrugBank databases. The pharmacological mechanism of cinobufotalin injection against lung cancer was determined b

SUBMITTER: Mao Y 

PROVIDER: S-EPMC7048923 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature