Chemical functionality of multidomain peptide hydrogels governs early host immune response.

ABSTRACT: Multidomain Peptide (MDP) hydrogels are nanofibrous materials with many potential biomedical applications. The peptide sequence design of these materials offers high versatility and allows for the incorporation of various chemical functionalities into the nanofibrous scaffold. It is known that host response to biomaterials is strongly affected by factors such as size, shape, stiffness, and chemistry. However, there is a lack of fundamental understanding of the host response to different MDP hydrogels. In particular, it is unknown what effect the chemical functionality displayed on the nanofiber has on biological activity. Here we evaluated the early inflammatory host response to four MDP hydrogels displaying amines, guanidinium ions, and carboxylates in a subcutaneous injection model. Whil

SUBMITTER: Lopez-Silva TL 

PROVIDER: S-EPMC7049098 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature