Mechanism for neurotransmitter-receptor matching.

ABSTRACT: Synaptic communication requires the expression of functional postsynaptic receptors that match the presynaptically released neurotransmitter. The ability of neurons to switch the transmitter they release is increasingly well documented, and these switches require changes in the postsynaptic receptor population. Although the activity-dependent molecular mechanism of neurotransmitter switching is increasingly well understood, the basis of specification of postsynaptic neurotransmitter receptors matching the newly expressed transmitter is unknown. Using a functional assay, we show that sustained application of glutamate to embryonic vertebrate skeletal muscle cells cultured before innervation is necessary and sufficient to up-regulate ionotropic glutamate receptors from a pool of different re

SUBMITTER: Hammond-Weinberger DR 

PROVIDER: S-EPMC7049162 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature