Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality.

ABSTRACT:

Introduction

Cognitive reserve predicts delayed diagnosis of Alzheimer's disease (AD) and faster postdiagnosis decline. The net impact of cognitive reserve, combining both prediagnosis and postdiagnosis risk, on adverse AD-related outcomes is unknown. We adopted a novel approach, using AD genetic risk scores (AD-GRS), to evaluate this.

Methods

Using 242,959 UK Biobank participants age 56+ years, we evaluated whether cognitive reserve (operationalized as education) modified associations between AD-GRS and mortality or hospitalization (total count, fall-related, and urinary tract infection-related).

Results

AD-GRS predicted mortality and hospitalization outcomes. Education did not modify AD-GRS effects on mortality, but had a nonsignificantly (interaction P = .10) worse

SUBMITTER: Filshtein TJ 

PROVIDER: S-EPMC7049165 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature