Association between gene polymorphisms of voltage-dependent Ca²⁺ channels and hypertension in the Dai people of China: a case-control study.

ABSTRACT:

Background

Abnormal calcium homeostasis related to the development of hypertension. As the key regulator of intracellular calcium concentration, voltage-dependent calcium channels (VDCCs), the variations in these genes may have important effects on the development of hypertension. Here we evaluate VDCCs variability with respect to hypertension in the Dai ethnic group of China.

Methods

A total of 1034 samples from Dai individuals were collected, of which 495 were used as cases, and 539 were used as controls. Blood pressure was measured using a standard mercury measurement method, three times with a rest for 5 min, and the average was used for analyses. Seventeen single nucleotide polymorphisms (SNPs) in the four protein-coding genes (CACNA1A, CACNA1C, CACNA1S, CACNB2) of VDCC

SUBMITTER: Huang L 

PROVIDER: S-EPMC7049211 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature