Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families.

ABSTRACT:

Purpose

To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized.

Methods

We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes.

Results

We found associations between PALB2 PVs and risk of female breast cancer (RR

SUBMITTER: Yang X 

PROVIDER: S-EPMC7049229 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature