Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years.

ABSTRACT:

Background

The kidney injury molecule-1 (KIM-1) has previously been associated with kidney function in rodents and humans. Yet its role as a predictive marker for future decline in kidney function has remained less clear.

Methods

At baseline (1991-1994), fasting plasma KIM-1 (p-KIM-1) was measured in 4739 participants of the population-based Malmö Diet and Cancer Study. Creatinine and cystatin C were used to calculate estimated glomerular filtration rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Collaboration 2012 creatinine-cystatin C equation at baseline and follow-up examination (2007-2012). Incident CKD was defined as an eGFR <60 mL/min/1.73 m2 at follow-up.

Results

During a mean follow-up time of 16.6 years, high p-KIM-1 leve

SUBMITTER: Schulz CA 

PROVIDER: S-EPMC7049260 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature