Biological Characteristics of Connection-Wise Resting-State Functional Connectivity Strength.

ABSTRACT: Functional connectivity is defined as the statistical dependency of neurophysiological activity between 2 separate brain areas. To investigate the biological characteristics of resting-state functional connectivity (rsFC)-and in particular the significance of connection-wise variation in time-series correlations-rsFC was compared with strychnine-based connectivity measured in the macaque. Strychnine neuronography is a historical technique that induces activity in cortical areas through means of local administration of the substance strychnine. Strychnine causes local disinhibition through GABA suppression and leads to subsequent activation of functional pathways. Multiple resting-state fMRI recordings were acquired in 4 macaques (examining in total 299 imaging runs) from which a group-aver

SUBMITTER: Pijnenburg R 

PROVIDER: S-EPMC7049309 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature