The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation.

ABSTRACT: Cell identity relies on the cross-talk between genetics and epigenetics and their impact on gene expression. Oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) is the first step of an active DNA demethylation process occurring mainly at enhancers and gene bodies and, as such, participates in processes governing cell identity in normal and pathological conditions. Although genetic alterations are well documented in multiple myeloma (MM), epigenetic alterations associated with this disease have not yet been thoroughly analyzed. To gain insight into the biology of MM, genome-wide 5hmC profiles were obtained and showed that regions enriched in this modified base overlap with MM enhancers and super enhancers and are close to highly expressed genes. Through the definition of

SUBMITTER: Chatonnet F 

PROVIDER: S-EPMC7049362 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature