Unique metastasis-associated lncRNA signature optimizes prediction of tumor relapse in lung adenocarcinoma.

ABSTRACT:

Background

Local relapses and metastases are primary causes of death in lung cancer patients. In the present study, we aimed to develop a prognostic signature based on metastasis-associated lncRNAs in patients with lung adenocarcinoma (LUAD).

Methods

Firstly, the potential metastasis-associated lncRNAs were identified by analyzing high-throughput data from The Cancer Genome Atlas (TCGA), and based on which, an lncRNA signature was constructed for prediction of relapse in LUAD patients using Cox proportional hazards regression analysis. Moreover, the prognostic performance of the lncRNA signature was evaluated using Kaplan-Meier survival analysis, time-dependent receiver operating characteristic (ROC) curve and Cox analysis, respectively. In addition, the potential metastasis

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7049496 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature