The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56^bright Natural Killer Cells.

ABSTRACT: The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56^bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56^bright NK cells, which were predominantly PLZF^lo

SUBMITTER: Hess LU 

PROVIDER: S-EPMC7049682 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature