Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic ¹³C Magnetic Resonance Spectroscopy.

ABSTRACT: Carbon-13 magnetic resonance spectroscopy (MRS) following oral intake of ¹³C-labeled glucose is the gold standard for imaging glycogen metabolism in humans. However, the temporal resolution of previous studies has been >13 minutes. Here, we describe a high-sensitivity ¹³C MRS method for imaging hepatic glycogen synthesis with a temporal resolution of 1 minute or less. Nuclear magnetic resonance spectra were acquired from the liver of 3 healthy volunteers, using a ¹³C clamshell radiofrequency transmit and paddle-shaped array receive coils in a 3 Tesla magnetic resonance imaging system. Following a 15-minute baseline ¹³C MRS scan of the liver, [1-¹³C]-glucose was ingested and ¹³C MRS data were acquired for an additional 1-3 ho

SUBMITTER: Stender S 

PROVIDER: S-EPMC7049683 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature