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Beating the ER: novel insights into FAM134B function and regulation.

ABSTRACT: To maintain cellular homeostasis, the endoplasmic reticulum (ER) necessitates a continuous removal of ER fragments via a selective, receptor-mediated, form of autophagy known as ER-phagy. In this issue of The EMBO Journal, Jiang et al (2020) shed light on how the best characterized autophagy receptor FAM134B mediates ER membrane fragmentation, the earliest event during ER-phagy. They propose a dynamic model for FAM134B protein oligomerization and ER membrane scission, which are driven by CAMK2B-mediated phosphorylation of the receptor and are altered in sensory neuropathy.

SUBMITTER: De Leonibus C

PROVIDER: S-EPMC7049802 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Beating the ER: novel insights into FAM134B function and regulation.

De Leonibus Chiara C Cinque Laura L Settembre Carmine C

The EMBO journal 20200219 5

To maintain cellular homeostasis, the endoplasmic reticulum (ER) necessitates a continuous removal of ER fragments via a selective, receptor-mediated, form of autophagy known as ER-phagy. In this issue of The EMBO Journal, Jiang et al (2020) shed light on how the best characterized autophagy receptor FAM134B mediates ER membrane fragmentation, the earliest event during ER-phagy. They propose a dynamic model for FAM134B protein oligomerization and ER membrane scission, which are driven by CAMK2B- ...[more]

PMID: 32073155

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MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.

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