Subtraction Ictal SPECT coregistered to MRI (SISCOM) as a guide in localizing childhood epilepsy.

ABSTRACT:

Objective

To assess feasibility and efficacy of subtraction ictal SPECT coregistered to MRI (SISCOM) for epilepsy localization in children who are candidates for resective surgery.

Methods

We retrospectively reviewed all patients ≤16 years with drug-resistant epilepsy screened for epilepsy surgery in the University Hospital of Leuven from January 2009 to January 2018. Fifty-eight hospitalizations for ictal SPECT and 51 SISCOM analyses in 44 patients were included. Mean age was 9.1 years. Hospitalizations for SISCOM were analyzed in terms of multiple variables affecting feasibility and efficacy. The localization of SISCOM was compared with the localization of the presumed epileptogenic zone (PEZ) as determined by video-EEG.

Results

SISCOM was feasible in terms of chron

SUBMITTER: Foiadelli T 

PROVIDER: S-EPMC7049808 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature