Persistent sodium current blockers can suppress seizures caused by loss of low-threshold D-type potassium currents: Predictions from an in silico study of K_v1 channel disorders.

ABSTRACT:

Objective

Ion channels belonging to subfamily A of voltage-gated potassium channels (K_v1) are highly expressed on axons, where they play a key role in determining resting membrane potential, in shaping action potentials, and in modulating action potential frequency during repetitive neuronal firing. We aimed to study the genesis of seizures caused by mutations affecting K_v1 channels and searched for potential therapeutic targets.

Methods

We used a novel in silico model, the laminar cortex model (LCM), to examine changes in neuronal excitability and network dynamics associated with loss-of-function mutations in K_v1 channels. The LCM simulates the activities of a network of tens of thousands of interconnected neurons and incorporates the kineti

SUBMITTER: Du J 

PROVIDER: S-EPMC7049813 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature