Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients.

ABSTRACT: Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorphisms in P. falciparum infection. Material and Methods. Ten single-nucleotide polymorphisms (SNPs), rs976748, rs1179246, rs2046068, rs1182844, rs2227508, rs2227513, rs2227478, rs2227481, rs2227491, and rs2227483, of IL-22 gene were genotyped through PCR-based assays of 250 P. falciparum infection. IL-22 gene promoter activity.

Results

We found that the rs2227481 TT genotype (odds ratio 0.254, confidenc

SUBMITTER: Aljarba NH 

PROVIDER: S-EPMC7049855 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature