Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.

ABSTRACT: We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients. For this purpose, we compared the expression of different activating and inhibitory receptors (KIR and non-KIR) and integrins on NK cells as well as their recent degranulation history between the patients and age-matched healthy controls. The study was conducted using freshly obtained peripheral blood samples from the study participants. Multiple color flow cytometry was used for these determinations. Our results show that NK cells from treatment-naïve CD patients expressed higher levels of activating KIR as well as other non-KIR activating receptors vis-à-vis healthy controls. They also showed increased frequencies of the cells ex

SUBMITTER: Samarani S 

PROVIDER: S-EPMC7049869 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature