Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia.

ABSTRACT: Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature. It also augments the activity of peripheral sympathetic nerves through activation of presynaptic angiotensin II receptors, thus contributing to sympathetic over-activity. Although some cells can synthesise angiotensin II locally, it is not known if this machinery is present in neurons closely coupled to the heart. Using a combination of RNA sequencing and quantitative real-time polymerase chain reaction, we demonstrate evidence for a renin-angiotensin synthesis pathway within human and rat sympathetic stellate ganglia, where significant alterations were observed in the spontaneously hypertensive rat stellate ganglia compared with Wistar st

SUBMITTER: Bardsley EN 

PROVIDER: S-EPMC7049903 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature