Prognostic factors of adjuvant chemotherapy discontinuation among stage III colon cancer patients: A survey of medical oncologists and a systematic review and meta-analysis.

ABSTRACT:

Background

Factors that are prognostic of early discontinuation of adjuvant chemotherapy among stage III colon cancer patients have yet to be described. To address this gap, a survey of medical oncologists and a systematic review and meta-analysis were conducted.

Methods

A survey was distributed in March 2019 to medical oncologists who treat colon cancer within Alberta, Canada. Clinicians were asked to rank the prognostic importance of a set of variables using a Likert scale and agreement was quantified using a weighted Cohen's kappa. In addition, we systematically searched four databases up to July 2019. Meta-analyses were conducted using a random-effects model.

Results

Of the 25 clinicians who were sent the survey, 14 responded. Overall, there was no agreement regar

SUBMITTER: Boyne DJ 

PROVIDER: S-EPMC7050079 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature