Radiation Therapy in the Definitive Management of Oligometastatic Prostate Cancer: The Johns Hopkins Experience.

ABSTRACT:

Purpose

The use of radiation therapy (RT) in consolidating oligometastatic prostate cancer (OPCa) is a rapidly evolving treatment paradigm. We review our institutional experience using metastasis-directed therapy in the definitive management of men with OPCa.

Methods and materials

Patients with OPCa treated with definitive RT were included. The Kaplan-Meier method and multivariable Cox regression analysis were performed to assess biochemical progression-free survival (bPFS) and time to next intervention. Cumulative incidence functions were used to calculate rates of local failure. Toxicity was assessed using Common Terminology Criteria for Adverse Events (version 4).

Results

This study analyzed 156 patients with OPCa and 354 metastatic lesions with median follow-up of

SUBMITTER: Deek MP 

PROVIDER: S-EPMC7050213 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature